A Study of Creation 
(With CD-Rom)

Hector Sabelli, M.D., Ph.D.





Louis Kauffman, Ph.D. 
Joseph V. Messer, M.D.
Linnea Carlson-Sabelli, Ph.D.APRN-BC, TEP
Arthur Sugerman, Ph.D. 
Minu K. Patel, M.Sc.
Lazar Kovacevic, B.S.E.E. 

with  the

Bios Data Analyzer
Arthur Sugerman, Hector Sabelli, 
Minu K. Patel, 
Louis Kauffman, 
Lazar Kovacevic



World World Scientific Press, 
Series on Knots and Everything - Vol 35


Bios, meaning life, explores the hypothesis that natural processes are creative (neither random, nor determined). Bios is a prototype for the complex patterns created by causal processes. This book (1) presents methods for identifying bios in empirical data; (2) demonstrates biotic patterns in physical, biological and economic processes; and (3) introduces bipolar (positive and negative) feedback as a mathematical model for the generation of bios. Turbulence is paradigmatic of chaos; heart rate variation is the prototype for bios. 

Creation Theory advances the hypothesis that the universe is creative and organized by universal and relatively simple mathematical forms. The interaction of paired opposites, such as elementary particles and biological sexes, constitute processes of mutual and bipolar feedback. They generate bios at all levels of organization, thereby contributing to cosmological, biological and human evolution. In turn, complex processes feedback and transform simpler ones. Simple processes have priority and energy. Complex processes have supremacy. The universe evolves towards an Infinite Attractor, not towards equilibrium, entropic decay, or randomness. 

Co-Creation is an ongoing process in which we are active participants. The concept of bipolar and mutual feedback suggests specific approaches for co-creation in clinical, social, ecological and personal settings.



This book focuses on a prototype of creative causal processes termed BIOS and how the concept can be applied to the physical world, in medicine and in social science. It presents methods for identifying creative features in empirical data; studies showing biotic patterns in physical, biological, and economic processes; mathematical models of bipolar (positive and negative) feedback that generate biotic patterns.

These studies support the hypothesis that natural processes are creative (not determined) and causal (not random) and that bipolar feedback plays a major role in their evolution. Simple processes precede, coexist, constitute and surround the complex systems they generate (priority of the simple). In turn, complex processes feedback and transform simpler ones (supremacy of the complex).

Key Features:

            Introduces the concept of bipolar feedback, a mathematical and natural process that generates bios, a pattern beyond chaos

            Demonstrates biotic patterns in cosmological, physiological, meteorological, and economic processes

            Introduces new methods for time series analysis, and includes ready to use programs for them in the CD-Rom

            Proposes a research program based on the concept of creative development as an alternative to deterministic and random models

            Advances a new theory of biological evolution


Author Hector Sabelli, M.D., Ph.D. is the Director of the Chicago Center for Creative Development, former Professor and Director of the Institute of Pharmacology, University of Litoral, Argentina, Professors and Chairman, Department of Pharmacology, Chicago Medical School, and Professor of Pharmacology and Associate Professor of Psychiatry at Rush University. He received his M.D. degree from the University of Buenos Aires, Argentina and did his Ph.D. thesis research in pharmacology at the Chicago Medical School. He received several awards in pharmacology, psychiatry, and psychodrama and a Doctorate Honoris Cause from the University of Rosario, Argentina. His work is published in Nature, Science, American Journal of Psychiatry, International Journal of General Systems, and in five books including Union of Opposites, A Comprehensive Theory of Natural and Human Processes (1989).


Louis Kauffman, Ph.D. is a mathematics professor at the University of Illinois at Chicago. He works in knot theory, differential topology and diagrammatic mathematics.

Joseph V. Messer, M.D. (Harvard Medical School), MACC, FACP, FCCP, FSCAI, FAHA, Professor of Medicine and Senior Attending Physician, Rush University Medical Center 

Linnea Carlson-Sabelli Ph.D (Nursing Science), APRN-BC (Advanced Practice Nurse, Psychiatric Mental Health Nursing, TEP (Trainer and Educator in Psychodrama Sociometry and Group Psychotherapy)  Associate Professor of Nursing, Department of Cmmmunity and Mental Health Nursing, Rush University Medical Center.

Arthur Sugerman, Ph.D. Senior Researcher, Chicago Center for Creative Development, and Ergo Development Inc. 

Minu K. Patel, M.Sc. (math), M.Sc. (stat), University of Illinois, Research Resources Center, Biostatistics Facility, and Medical-Surgical Nursing Department. 

Lazar Kovacevic, B.S.E.E. (University of Belgrade), Research Associate, Chicago Center for Creative Development.



 Foreword by Louis H. Kauffman

Dedication and Acknowledgements

Introduction: How is the Universe that It Creates a Human Heart? (read)


Part 1. Creative Processes and Mathematical Models 

1. A Research Program: A Science of Creative Processes (read excerpt)

2. On the Shoulders of Giants (read excerpt)

3. Mathematical Ideas: Bios and Biotic Feedback (with L. Kauffman) (read excerpt)


Part 2. Methods and Empirical Studies 

4. Bios Data Analysis (read excerpt)

4.1 Designing Methods by Studying Cardiac Patterns

4.2 Process Statistics: Diversification, Asymmetry and 1/f Novelty (with M. Patel)

4.3 Phase Plane of Opposites: Energy and Information (with L. Carlson-Sabelli)

4.4 Information: Repetition, Rise and Fall (with M. Patel)

4.5 Trigonometric Analysis of Opposites

4.6 Novelty, Causation, and Recurrence (Isometry Method) (with A. Sugerman)

4.7 Complexes: Recurrence and Wavelet Plots

4.8 Arrangement, a Measure of Nonrandom Complexity

4.9 Simplicity and Complexity: Embedding Plots (with A. Sugerman)

5. The Biotic Pattern of Heart Rate Variation (with J. Messer) (read excerpt)

6. The Biotic Expansion of the Universe (with L. Kovacevic) (read excerpt)

7. Novelty in DNA (read excerpt)


Part 3. A Theory of Natural Creation

 8. Bios Hypothesis (read excerpt)

9. Creation Theory (read excerpt)

10. Mathematical Genesis (read excerpt)


Part 4. Co-Creation

 11. Biotic Thermodynamics: Entropy as Diversity (read excerpt)

12. The Infinite Attractor of Evolution (read excerpt)

13. Biotic Evolution (read excerpt)

14. Biotic Earth, Biotic Climate (read excerpt)

15. Biotic Processes in Economics (read excerpt)

16. Biological Priority, Psychological Supremacy (read excerpt)

17. Co-Creation Practice: Education, Nursing and Psychodrama (with L. Carlson-Sabelli) (read excerpt)

18. A Manner of Thinking: Mathematical Priority and Psychological Supremacy (read excerpt)

For more information, please visit the publisher's web site.

World Scientific Publishing Company
Pub. Date: March 2005
Pages: 668pp
ISBN: 981-256-103-X (Hard Cover)
Price: US$86/52


Posted June 11, 2005 LCS